等待内容更新

【药品名称】

  通用名称：枸橼酸他莫昔芬片

  商品名称：枸橼酸他莫昔芬片(护佑)

  英文名称：Tamoxifen Citrate Tablets

 

【主要成份】 枸橼酸他莫昔芬。

【成 份】

   分子量：C26H29NO·C6H8O7

【性 状】 本品为白色片。

【适应症/功能主治】 1．治疗女性复发转移乳腺癌。 2．用作乳腺癌手术后转移的辅助治疗，预防复发。

【规格型号】 10mg*60s

【用法用量】 口服，每次10mg(1片)，每天2次，也可每次20mg(2片)，每天2次。

【不良反应】 治疗初期骨和肿瘤疼痛可一过性加重继续治疗可逐渐减轻。少数病人有不良反应。 其中胃肠道反应：食欲不振、恶心、呕吐、腹泻。 生殖系统：月经失调，闭经，阴道出血，外阴瘙痒，子宫内膜增生，内膜息肉和内膜癌。 皮肤：颜面潮红，皮疹，脱发。 骨髓：偶见白细胞和血小板减少。肝功偶见异常。 眼睛：长时间（17个月以上）大量（每天240-320mg）使用可出现视网膜病或角膜浑浊。罕见的、需引起注意的不良反应：精神错乱，肺栓塞（表现为气短），血栓形成，无力，嗜睡。

【禁 忌】 有眼底疾病者禁用。

【注意事项】 1.有肝功能异常者应慎用。如有骨转移，在治疗初期需定期查血钙。 2.运动员慎用。
请仔细阅读说明书并遵医嘱使用。

【儿童用药】 尚不明确。

【老年患者用药】 尚不明确。

【孕妇及哺乳期妇女用药】 对胎儿有影响，妊娠，哺乳期妇女禁用。

【药物相互作用】 雌激素可影响本品治疗效果，抗酸药、西咪替丁、雷尼替丁等在胃内改变pH值，使本品肠衣提前分解，对胃有刺激作用。

【药物过量】 尚不明确。

【药理毒理】 他莫昔芬为非固醇类抗雌激素药物。其结构与雌激素相似，存在Z型和E型两个异构体。两者物理化学性质各异，生理活性也不同，E型具有弱雌激素活性，Z型则具有抗雌激素作用。如果乳癌细胞内有雌激素受体（ER），则雌激素进入肿瘤细胞内，与其结合，促使肿瘤细胞的DNA和m-RNA的合成，刺激肿瘤细胞生长。而他莫昔芬Z型异构体进入细胞内，与ER竞争结合，形成受体复合物，阻止雌激素作用的发挥，从而抑制乳腺癌细胞的增殖。

【药代动力学】 本品为口服，吸收迅速。口服20mg后6～7.5小时，在血中达最高浓度，T1/2β:7～14小时，4天或4天后出现血中第二高峰，可能是肝肠循环引起，T1/2β大于7天。其排泄较慢，主要从粪便排泄，约占4/5，尿中排泄较少，约1/5。口服后13天时仍可从粪便中检测得到。

【贮 藏】 遮光，密封保存。

 

 

 

 

 

 

 

 

 

 

Description

This medicine acts on estrogen receptor of breast cancer cell to suppress estrogen action and growth of cancer cell.

Presentation

50tablets

Feature

White tablet

Active Ingredients

Tamoxifen citrate

Effect/Efficacy

This medicine acts on estrogen receptor of breast cancer cell to suppress estrogen action and growth of cancer cell.
It is usually used to treat breast cancer.

Usage/Dosage

〇 General dosage:
　　● For adults, take 2 tablets (20mg of tamoxifen) a day, in 1 to 2 divided doses.
　　● The dosage may be adjusted according to symptoms of the patient.
　　● DO NOT exceed the daily maximum dosage, 4 tablets (40mg). Strictly follow the instructions.

〇 If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
〇 If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
〇 Do not stop taking this medicine unless your doctor instructs you to do so.

Cautions

Contraindication

● The most commonly reported adverse reactions are following symptoms. If any of these symptoms occur, consult with your doctor or pharmacist.
　　　-　amenorrhea, menstrual abnormality, genital bleeding, nausea, vomiting, anorexia, hot flash and flushing.

● The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.

　　　-　reduced visual acuity, blurred vision [vision abnormality/disturbance]
　　　-　local pain/tenderness, erythema, edema [thromboembolism, phlebitis]
　　　-　genital bleeding, menstrual abnormality (hypermenorrhea, lower abdominal/low back pain, etc.), menstrual irregularity [uterine fibroid, endometrial polyp, endometrial hyperplasia, endometriosis]
　　　-　fever, dry cough, respiratory distress [interstitial pneumonia]
　　　-　swelling around eyelid/lip, rash, shortness of breath [anaphylactoid symptoms, angioedema]

The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.