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PRORENAL tablets

（Limaprost Alfadex）利马前列素片

 

类别名称
口服前列腺素E1衍生物的制剂
商標名
PRORENAL
一般名
リマプロスト　アルファデクス　Limaprost Alfadex
化学名
(2E)-7-{(1R, 2R, 3R)-3-Hydroxy-2-[(1E,3S, 5S)-3-hydroxy-5-methylnon-1-en-1-yl]-5-oxocyclopentyl}hept-2-enoic acid －α-cyclodextrin
分子式
C22H36O5・xC36H60O30
分子量
380.52〔ただし、リマプロスト(C22H36O5)として〕
性状
它是一种白色粉末。易溶于水，略溶于甲醇，乙醇（99.5）非常微溶，并在乙酸乙酯中几乎不溶。这是吸湿性。
药效药理
1.末梢循环障碍改善作用
通过在股动脉（后）循环衰竭模型和肾上腺素月桂酸给药周创建，麦角胺中皮下创建的周边（尾部）循环衰竭模型，抑制缺血性损害的发展。（鼠）
2.增加的血流量，皮肤温度上升作用
（1）增加股骨动脉血流及后肢皮肤血流量，但增加后爪皮肤温度升高，血液流量增加作用并不受腰交感神经节切除。（狗）
（2）当口服施用给患者血栓闭塞性脉管炎，皮肤温度的周侧（脚背，跖）增加。
3.对血小板的作用
(1) 血小板粘着抑制作用
1）当口服给药时，以血栓性疾病患者，血小板粘附能力降低。
2）抑制血小板粘附，50％抑制浓度是0.186ng/ mL的如利马前列素（豚鼠，体外）。此外，在口服给药时，抑制血小板粘附（豚鼠，离体）。
（2）血小板凝集抑制作用
1）当口服给药时，以血栓性疾病患者，抑制血小板聚集。这种效应的强度相当于前列腺素（体外）。
2）通过各种聚集诱导抑制血小板聚集，也离解ADP聚合（豚鼠，体外）。此外，在口服给药，抑制血小板聚集（豚鼠离体）。
3）血小板的环状AMP含量显着增加，另外，抑制产生血栓烷A2的（豚鼠，体外）。
4. 抗血栓作用
在实验中，以形成由电刺激血栓肠系膜动脉，以剂量依赖的方式血栓形成升高阈值电压。（豚鼠）
5.神经组织血流量增加作用
（1）在压缩模型通过将球囊插入第六腰椎的硬脑膜马尾，改善马尾神经组织血流量。（狗）
（2）在第四和第六腰椎管模型通过将硅橡胶以改善马尾神经组织血流量压缩马尾。（鼠）
（3）在结扎坐骨神经结扎模型中的右后两个位置，提高了连接中间部分的坐骨神经组织血流量的坐骨神经。（鼠）
6.神经功能的改善作用
（1）在压缩模型通过将球囊插入第七腰椎的硬脑膜马尾抑制神经传导速度的降低。（狗）
（2）在结扎坐骨神经结扎模型中的右后肢的四个位置的坐骨神经，它抑制了结扎侧大腿肌肉的热刺激引起的肌肉放电持续时间的延长。（鼠）
7.痛觉过敏的改善作用
在右后腿两个位置连接的坐骨神经结扎模型，坐骨神经，提高结扎一侧的痛觉过敏。（鼠）
8.步行障碍改善作用
在模型通过将硅橡胶到第四和第六腰椎管，以改善步行距离的减小压缩马尾。（鼠）
适应病
1.与血栓闭塞性脉管炎，改善疼痛和寒冷等缺血症状相关的溃疡
2.获取的腰椎管狭窄症（SLR测试正常，患者双侧间歇性跛行）症状（下肢疼痛，下肢麻痹）与和的行走能力的改善相关联。
用法与用量
1.与血栓闭塞性脉管炎相关的溃疡，疼痛和寒冷等的缺血症状，成人的改善，口服给药分为每天三次30μg的如利马前列素。
2.后天性腰椎管狭窄症（SLR测试正常，患者双侧间歇性跛行）症状（下肢疼痛，下肢麻木）由于改善和行走能力，日常正常成人的利马前列素口服施用一含15μg三次。
包装规格
Prorenal片
5μg：
[PTP]100片（10片×10），210片（21片×10），500片（10片×50），1050片（21片×50）
[瓶装]500粒
制造厂商
大日本住友制药有限公司

 

 

 

 

 

 

 

 

 

 

 

 

Description

This medicine dilates the peripheral artery and suppresses platelet aggregation to relieve symptoms such as numbness/pain in limbs and coldness. It also relieves leg numbness/pain caused by lumbar spinal stenosis and improves walking ability.

It is usually used for the improvement of ischemic symptoms such as ulcer, pain and coldness caused by thromboangiitis obliterans. It is also used for the improvement of subjective symptoms such as leg pain/numbness and walking ability caused by acquired lumber spinal stenosis. ( Patients who are proved normal in SLR test and have bilateral intermittent claudication.)

Presentation

42Tablets

Feature

White tablet

Active Ingredients

Limaprost alfadex

Effect/Efficacy

This medicine dilates the peripheral artery and suppresses platelet aggregation to relieve symptoms such as numbness/pain in limbs and coldness. It also relieves leg numbness/pain caused by lumbar spinal stenosis and improves walking ability.

It is usually used for the improvement of ischemic symptoms such as ulcer, pain and coldness caused by thromboangiitis obliterans. It is also used for the improvement of subjective symptoms such as leg pain/numbness and walking ability caused by acquired lumber spinal stenosis. ( Patients who are proved normal in SLR test and have bilateral intermittent claudication.)

Usage/Dosage

● General dosage:
Thromboangiitis obliterans:
- In general, for adults, take 2 tablets (10μg of Limaprost) at a time, 3 times a day.
Acquired lumbar spinal stenosis:
- In general, for adults, take 1 tablet (5μg of Limaprost) at a time, 3 times a day.
● Strictly follow the instructions in any case.
● If you miss a dose, take a dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and follow your regular dosing schedule. You should never take two doses at one time.
● If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
● Do not stop taking this medicine unless your doctor instructs you to do so.

Cautions

Contraindication

● The most commonly reported adverse reactions are following symptoms. If any of these symptoms occur, consult with your doctor or pharmacist.
- rash, itch, hives, photosensitivity, bleeding and diarrhea.

● The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
- general malaise, loss of appetite, yellowing of the skin and the whites of the eyes [liver dysfunction, jaundice]

The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.