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GRACEVIT 西他沙星水合物

通用名称西他沙星水合物 Sitafloxacin hydrate
品牌名称GRACEVIT
产地|公司日本(Japan) | Daiichi Sankyo(Daiichi Sankyo)
技术状态原研产品
成分|含量50mg
包装|存储20片/盒 室温
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通用中文 西他沙星水合物 通用外文 Sitafloxacin hydrate
品牌中文 品牌外文 GRACEVIT
其他名称
公司 Daiichi Sankyo(Daiichi Sankyo) 产地 日本(Japan)
含量 50mg 包装 20片/盒
剂型给药 片剂口服 储存 室温
适用范围 用于严重的和耐药菌引起的细菌感染的治疗
通用中文 西他沙星水合物
通用外文 Sitafloxacin hydrate
品牌中文
品牌外文 GRACEVIT
其他名称
公司 Daiichi Sankyo(Daiichi Sankyo)
产地 日本(Japan)
含量 50mg
包装 20片/盒
剂型给药 片剂口服
储存 室温
适用范围 用于严重的和耐药菌引起的细菌感染的治疗

使用说明书

(免责声明:本说明书仅供参考,不作为治疗的依据,不可取代任何医生、药剂师等专业性的指导。本站不提供治疗建议,药物是否适合您,请专业医生(或药剂师)决定。)
等待内容更新

中文说明

(免责声明:本说明书仅供参考,不作为治疗的依据,不可取代任何医生、药剂师等专业性的指导。本站不提供治疗建议,药物是否适合您,请专业医生(或药剂师)决定。)

【药品名称】西他沙星片
【英文名称】sitafloxacin 
【商品名称】GRACEVIT TABLETS(片) GRACEVIT FINE GRANULES(细粒)
【日文药名】グレースビット錠50mg/グレースビット細粒10%
【化学名称】7-[(7s)-7-氨基-5-氮杂螺[2.4]庚-5-基]-8-氯-6-氟-1-[(1r,2s)-cis-2-氟环丙基]-1,4-二氢-4-氧代-3-喹啉羧酸 分子式:2(c19h18clf2n3o3)·3(h2o) 
分子量:873.67 cas号:127254-12-0 2、
【剂    型】片剂,细粒剂 
【规    格】50mg 
【适 应 症】用于严重的和耐药菌引起的细菌感染的治疗 
【用法用量】以呼吸道感染、尿路感染、耳鼻喉科感染、牙科·口腔外科感染及性病感染患者为对象的临床试验中,西他沙星每次50mg,1日2次或每次100mg,1日2次给药。 
【药理作用】本品系一新颖的n-1-氟环丙基喹诺酮,对耐甲氧西林金黄色葡萄。
【开发单位】日本第一制药

 

 


日本批准广谱抗生素西他沙星水合物片剂和细粒剂上市
日本厚生省批准第一制药三共株式会社(Daiichi Sankyo)的广谱抗生素西他沙星水合物50 mg片和10%细粒剂(sitafloxacin hydrate,商Gracevit)上市,用于治疗严重难治的细菌感染。
本品系一新颖的N-1-氟环丙基喹诺酮,对耐甲氧西林金黄色葡萄球菌、耐甲氧西林表皮葡萄球菌、厌氧菌(包括脆弱类杆菌)以及支原体、衣原体等均具较强的抗菌活性。
化学结构上有一顺式(1R,5R)-2-氟环丙胺基团,显示良好的药代动力学特性,且可减少不良反应。该药不仅显著增强抗革兰阳性菌活性,而且对临床分离的许多耐氟喹诺酮类的菌株也具抗菌活性。
本品体外抗菌活性的研究表明,其具广谱抗菌作用,不仅对革兰阴性菌有抗菌活性,而且对革兰阳性菌以及对许多临床常见耐氟喹诺酮类菌株也有良好杀菌作用。本品口服吸收好、生物利用度大于70%,组织分布广,在中枢神经系统外的多种组织中的药物浓度均高于血清药物浓度,因此,本品可望成为治疗呼吸道、泌尿生殖道、腹腔以及皮肤软组织等单一或混合细菌感染的重要药物。

 

 

外文说明

(免责声明:本说明书仅供参考,不作为治疗的依据,不可取代任何医生、药剂师等专业性的指导。本站不提供治疗建议,药物是否适合您,请专业医生(或药剂师)决定。)

Description

This is a new quinolone oral antibacterial to inhibit DNA replication of bacteria at the time of infection, and shows antibacterial action.
It is usually used in the treatment of various infections such as respiratory infection, urologic infection, gynecologic infection, otorhinological infections, and dental infection.

Presentation

20tablets

Feature

White to slightly yellowish white tablet

Active Ingredients

Sitafloxacin hydrate

Effect/Efficacy

This is a new quinolone oral antibacterial to inhibit DNA replication of bacteria at the time of infection, and shows antibacterial action.
It is usually used in the treatment of various infections such as respiratory infection, urologic infection, gynecologic infection, otorhinological infections, and dental infection.

Usage/Dosage

〇 General dosage is as follows.

● For adults, take 1 tablet (50 mg of sitafloxacin) at a time, twice daily, or 2 tablets (100 mg) at a time, once daily. If the effect is insufficient, the dosage may be increased to 2 tablets (100 mg) at a time, twice daily. Strictly follow the instructions.

〇 If you miss a dose, take a dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
〇 If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.

Cautions


Contraindication

● The most commonly reported adverse reactions are following symptoms. If any of these symptoms occur, consult with your doctor or pharmacist.
  - diarrhea, loose stool, headache, and rash

● The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
  - pale face, cold sweat, dizziness, breathing difficulty, eruption, angioedema [shock, anaphylaxis]
  - fever, loss of appetite, rash [oculomucocutaneous syndrome]
  - anorexia, general malaise, yellowing in the skin or conjunctiva [hepatic dysfunction]
  - general malaise, decrease of urine putput, swelling [acute renal failure]
  - nausea, vomiting, stomachache, frequent diarrhea [pseudomembranous colitis]
  - sweating, palpitation, lassitude [hypoglycaemia]

Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.