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药品名称:

通用名称：米索前列醇片
英文名称：Cytotec (Misoprostol Tablets)
商品名称：喜克馈

成分:

米索前列醇

适应症:

本品用于治疗十二指肠溃疡和胃溃疡，包括关节炎患者由于服用非甾体类抗炎药(NSAID)所引起的十二指肠溃疡和胃溃疡，保障其仍可继续使用NSAID治疗。本品还可用于预防使用NSAID所引起的溃疡。

用法用量:

成人：
治疗十二指肠溃疡、胃溃疡、及由NSAID引起的消化性溃疡：
每日0.8mg，在早饭、和/或中饭、晚饭时及睡前（分2或4次服用）。即使症状很快得到缓解，开始时治疗应最少持续4周。大多数患者的溃疡可在4周内愈合，但如需要疗程可延长至8周。如有溃疡复发可开始新的疗程。

禁忌:

米索前列醇禁用于以下患者：
禁用于孕妇或者无法排除妊娠的妇女，或者计划妊娠的妇女，由于在妊娠期间，米索前列醇会增加子宫的张力和收缩，可能引起胎儿不完全或完全流产。妊娠中使用与出生缺陷相关。
已知对米索前列醇或者本品任何其他成份或者其他前列腺素过敏者。

注意事项:

接受NSAID治疗的患者使用米索前列醇，可能发生胃肠道出血、溃疡和穿孔。即使是在无胃肠道症状的情况下，医生以及患者仍需警惕溃疡的发生，并且在适当的条件下，在使用本品之前应进行内镜和活组织检查，以确保上消化道无恶性病变。这些检查以及任何其他临床医生认为有必要的检查均应以合适的间隔时间重复进行，用于随访。

不良反应:

将不良反应术语依据发生率进行分类如下：
单次剂量不超过0.2mg并与食物一起服用，以及若需要服用抗酸剂时，避免使用含镁的抗酸剂，均可降低腹泻发生的风险。
当同时给予非甾体抗炎药(NSAID)时，与喜克馈相关的不良事件的类型相似。
临床试验：
在临床试验中，超过15000例患者和受试者至少接受过一次剂量的米索前列醇治疗。不良反应主要累及消化系统。
...

相互作用:

NSAIDs与米索前列醇同时使用导致转氨酶水平升高和外周水肿的病例罕见。
本品主要经脂肪酸氧化系统代谢，对肝脏P450酶系统无不良影响。与安替比林或地西泮联合应用时，未发现具有临床意义的药代动力学相互作用。在多次给予米索前列醇时，观察到普萘洛尔的浓度有一定程度的升高（AUC平均约上升20%，Cmax平均约上升30%）。

Description

This medicine suppresses gastric acid secretion and protects gastric mucosa.
It is usually used to treat gastric ulcer and duodenal ulcer attributable to long-term administration of nonsteroidal antiinflammatory drugs.

Presentation

100 tablets

Feature

white tablet (hexagon), major axis: 9.2 mm, minor axis: 8.4 mm, thickness: 3.5 mm

Active Ingredients

Misoprostol 200 mcg

Effect/Efficacy

This medicine suppresses gastric acid secretion and protects gastric mucosa.
It is usually used to treat gastric ulcer and duodenal ulcer attributable to long-term administration of nonsteroidal antiinflammatory drugs.

Usage/Dosage

In general, for adults, take 1 tablet (200 mcg of the active ingredient) at a time, four times daily, after each meal and before bedtime. The dosage may be adjusted according to the age or symptoms. Strictly follow the instructions.
If you miss a dose, skip the missed dose and follow your regular dosing schedule from the next meal. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.

Cautions

If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you are pregnant, possibly pregnant/possibly getting pregnant, or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

For women, avoid getting pregnant during treatment with this medicine since it may cause spontaneous abortion. If you notice any signs of pregnancy, stop taking this medicine and consult with your doctor immediately.

Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
Discard the remainder. Do not store them. If you dispose of unused medicines, ask the pharmacist and the
medical institution how to discard them.

Contraindication

The most commonly reported adverse reactions include diarrhea, loose stool, abdominal pain, abdominal bloating, nausea, indigestion, rash, itch and hives. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
respiratory distress, shivering, facial pallor [shock, anaphylactoid symptoms]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.