药品首页 >
日本直供

Cefcapene Pivoxil Hydrochloride 盐酸头孢卡品酯

通用名称盐酸头孢卡品酯 Cefcapene pivoxil hydrochloride hydrate
品牌名称Cefcapene Pivoxil Hydrochloride
产地|公司日本(Japan) | TOWA(TOWA)
技术状态通用产品
成分|含量75mg
包装|存储50片/盒 室温
微信客服
Xirou_Canada
微信ID
(8:00-15:00)
服务时间
通用中文 盐酸头孢卡品酯 通用外文 Cefcapene pivoxil hydrochloride hydrate
品牌中文 品牌外文 Cefcapene Pivoxil Hydrochloride
其他名称 Flomox
公司 TOWA(TOWA) 产地 日本(Japan)
含量 75mg 包装 50片/盒
剂型给药 片剂口服 储存 室温
适用范围 适用于敏感菌所致的呼吸道感染如肺炎、支气管炎、咽喉炎、扁桃体炎等;中耳炎;鼻窦炎;尿路感染如淋病、肾盂肾炎、膀胱炎;皮肤与皮肤组织感染等;胆道感染等。
通用中文 盐酸头孢卡品酯
通用外文 Cefcapene pivoxil hydrochloride hydrate
品牌中文
品牌外文 Cefcapene Pivoxil Hydrochloride
其他名称 Flomox
公司 TOWA(TOWA)
产地 日本(Japan)
含量 75mg
包装 50片/盒
剂型给药 片剂口服
储存 室温
适用范围 适用于敏感菌所致的呼吸道感染如肺炎、支气管炎、咽喉炎、扁桃体炎等;中耳炎;鼻窦炎;尿路感染如淋病、肾盂肾炎、膀胱炎;皮肤与皮肤组织感染等;胆道感染等。

使用说明书

(免责声明:本说明书仅供参考,不作为治疗的依据,不可取代任何医生、药剂师等专业性的指导。本站不提供治疗建议,药物是否适合您,请专业医生(或药剂师)决定。)
等待内容更新

中文说明

(免责声明:本说明书仅供参考,不作为治疗的依据,不可取代任何医生、药剂师等专业性的指导。本站不提供治疗建议,药物是否适合您,请专业医生(或药剂师)决定。)

【通用名】盐酸头孢卡品酯 
【英文名】cefcapene pivoxil hydrochloride 
【商品名】Flomox 
【CAS】 
135889-00-8 (cefcapene); 
105889-45-0 (cefcapene pivoxil); 
147816-23-7 (anhydrous cefcapene pivoxil hydrochloride) ; 
147816-24-8 (cefcapene pivoxil hydrochloride); 
【分子式】C23H29N5O8S2,HCl,H2O 
【化学名】Pivaloyloxymethyl (+)-(6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-pentenamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid carbamate monohydrochloride monohydrate 

【剂型】片剂 
【规格】75mg,100mg 
【用法用量】口服75mg、150mg 
【临床试验】 
对153例患者,每天200-600mg、28d,临床有效率胆道感染为95%,急性乳腺炎100%,伤口感染80%,其他皮肤感染80。
【药理作用】 
本品是第四代可口服头孢类抗生素,药理研究表明,对好氧革兰阳性菌的MSSA的MIC80为3.13μg/mL,与头孢替安、头孢克洛相同、对肺炎链球菌的MIC80≤0.1μg/mL,优于头孢克洛,与头孢托仑相当,对耐青霉素(含中等程度耐药)的肺炎链球菌的活性很强,MIC80为0.78μg/mL。对革兰阴性菌中的弗氏柠檬酸杆菌、阴沟肠杆菌、雷氏普罗威登斯菌、黏膜炎布兰汉氏球菌、黏质沙雷菌比头孢托仑、头孢替安强。对变形杆菌属、流感嗜血杆菌、摩氏摩根氏菌、淋球菌的活性比头孢克洛、头孢替安强,与头孢特仑相当。对耐氨苄西林的流感嗜血杆菌有很强的活性,MIC80为0.05μg/mL。对厌氧菌的活性是对比药中最强的。
本品是头孢类抗生素的口服前药,口服后在肠道中经酯酶水解,生成活性的头孢菌素化合物S-1006,新戊酸和甲醛。S-1006具有广泛的抗菌作用,对分离得到的金黄色葡萄球菌IC90为2μg/mL,对链球菌A,链球菌B,链球菌C,链球菌F,链球菌G以及肺炎链球菌的IC90≤0.12μg/mL,对所有分离得到的流感嗜血杆菌的IC90≤0.06μg/mL,对肠杆菌科细菌的IC50≤2μg/mL。本品对β-内酰胺酶TEM-1亚型稳定,但会被TEM-3,TEM-5,PSE-1及PSE-4亚型的β-内酰胺酶水解,也可被肠杆菌,摩根氏菌等细菌染色体的β-内酰胺酶所水解。
在动物研究中表明,本品可保护小鼠免遭肺炎链球菌和大肠杆菌的感染,其作用比头孢克罗和头孢地尼强。但抗金黄色葡萄球菌系统感染的作用比二者低。在对临床分离的呼吸道感染细菌的抗菌试验中,本品对青霉素敏感的肺炎链球菌的活性和青霉素,氨苄西林、头孢托仑酯的活性相同;比头孢克罗、头孢地尼和红霉素弱。但对产生β-内酰酶或不产生β-内酰胺酶的流感嗜血杆菌有较好的抗菌作用。

 

 

 

 

 

 

外文说明

(免责声明:本说明书仅供参考,不作为治疗的依据,不可取代任何医生、药剂师等专业性的指导。本站不提供治疗建议,药物是否适合您,请专业医生(或药剂师)决定。)

Description

This medicine is a cephem antibiotic and has an antibacterial effect by inhibiting bacterial cell wall synthesis.
It is usually used for the treatment of a wide range of bacterial infections including the skin, respiratory organ, urinary tract, gynecology, dental and oral surgical infections, etc.

Presentation

50 tablets

Feature

white tablet, diameter 7.65 mm, thickness 3.6 mm

Active Ingredients

Cefcapene pivoxil hydrochloride hydrate 75mg

Effect/Efficacy

This medicine is a cephem antibiotic and has an antibacterial effect by inhibiting bacterial cell wall synthesis.
It is usually used for the treatment of a wide range of bacterial infections including the skin, respiratory organ, urinary tract, gynecology, dental and oral surgical infections, etc.

Usage/Dosage

In general, for adults, take 100 mg (titer) of the active ingredient at a time, 3 times daily after meals. For patients with refractory infections or those for whom the usual dosage is insufficient, take 150 mg (titer) of the active ingredient at a time, 3 times daily after meals. The dosage may be adjusted according to the disease, age and symptoms.This preparation contains 75 mg (titer) of the active ingredient in a tablet. Strictly follow the instructions.
If you miss a dose, take the missed dose as soon as possible. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
Do not stop taking this medicine unless your doctor instructs you to do so.

Cautions

If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Keep out of the reach of children. Store away from direct sunlight, heat and moisture.
Discard the remainder. Do not store them.

Contraindication

The most commonly reported adverse reactions include rash, hives, itch, redness, erythema, swelling, fever, arthralgia, nausea and loss of appetite. If any of these symptoms occur, consult with your doctor or pharmacist.
The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
feeling unwell, intraoral abnormal feeling, dizziness [shock, anaphylactoid symptoms]
sore throat, anaemia, bleeding tendency [agranulocytosis, thrombocytopenia, hemolytic anemia]
fever, erythema/bulla, bloodshot eyes [toxic epidermal necrolysis, mucocutaneous ocular syndrome, erythroderma (exfoliative dermatitis)]
fever, dry cough, resipiratory distress [interstitial pneumonia, eosinophilic pneumonia]
general malaise, loss of appetite, yellowness in the skin or in the white of eyes [fulminant hepatitis, hepatic function disorder, jaundice]
The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.