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Camostat mesilate 甲磺酸卡莫司他

通用名称甲磺酸卡莫司他 Camostat mesilate
品牌名称Camostat mesilate
产地|公司日本(Japan) | TOWA(TOWA)
技术状态通用产品
成分|含量100mg
包装|存储100片/盒 室温
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通用中文 甲磺酸卡莫司他 通用外文 Camostat mesilate
品牌中文 品牌外文 Camostat mesilate
其他名称 FOY-305, Foipan
公司 TOWA(TOWA) 产地 日本(Japan)
含量 100mg 包装 100片/盒
剂型给药 片剂 口服 储存 室温
适用范围 缓解慢性胰腺炎的急性症状, 术后返流性食管炎和肠瘘
通用中文 甲磺酸卡莫司他
通用外文 Camostat mesilate
品牌中文
品牌外文 Camostat mesilate
其他名称 FOY-305, Foipan
公司 TOWA(TOWA)
产地 日本(Japan)
含量 100mg
包装 100片/盒
剂型给药 片剂 口服
储存 室温
适用范围 缓解慢性胰腺炎的急性症状, 术后返流性食管炎和肠瘘

使用说明书

(免责声明:本说明书仅供参考,不作为治疗的依据,不可取代任何医生、药剂师等专业性的指导。本站不提供治疗建议,药物是否适合您,请专业医生(或药剂师)决定。)
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中文说明

(免责声明:本说明书仅供参考,不作为治疗的依据,不可取代任何医生、药剂师等专业性的指导。本站不提供治疗建议,药物是否适合您,请专业医生(或药剂师)决定。)

甲磺酸卡莫司他(CAMOSTAT MESILATE,FOIPAN)

【中文品名】甲磺酸卡莫司他

【药效类别】消化器官用药

【通用药名】CAMOSTAT MESILATE

【别  名】FOY-251, FOY-305, Foipan 

 

关键字:甲磺酸卡莫司他(CAMOSTAT MESILATE FOIPAN)

【中文品名】甲磺酸卡莫司他
【药效类别】消化器官用药
【通用药名】CAMOSTAT MESILATE
【别  名】FOY-251, FOY-305, Foipan
【化学名称】 N,N-Dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate monomethanesulfonate
【分 子 式】C20H22N4O5·CH4O3S
【分 子 量】494.52

【开发单位】小野制药
【首次上市】1985年,日本
【用  途】是一种口服有效的蛋白酶抑制药,用于缓解慢性胰腺炎的急性症状,还被批准用于术后返流性食管炎和肠瘘。

药理作用研究 
1)胰腺炎胰腺炎是由胰腺的蛋白酶引起的,同时加重胰腺自身消化的疾病。该蛋白酶由胰腺的酶原产生并排泄,少量胰蛋白酶经活化后,水解胰腺的组织蛋白而引起胰腺炎,许多严重的胰腺炎病例可导致多个器官坏死。选择性抑制胰蛋白酶的合成抑制剂对胰腺炎的治疗起重要作用。甲磺酸卡莫他特是临床上用于治疗慢性胰腺炎的口服有效的抑制剂。
2)胃切除后的返流性食管炎,胰蛋白酶抑制剂能治疗胃切除后十二指肠分泌液返流所引起的返流性食管炎,这种疾病是直接由十二指肠返流分泌液中所含的牛磺胆酸和胰蛋白酶的协同作用所引起的。在大鼠和狗的研究模型中,口服甲磺酸卡莫他特能有效地预防和治疗胃切除后的返流性食管炎。
3)肾炎,许多病例的肾小球内肾炎是由于免疫系统紊乱和密切参与的凝血血纤蛋白溶解、激肽和补体系统等生理过程的恶化而引起的,已试用介导上述损伤的抑制剂和血小板聚集作用进行临床治疗。甲磺酸卡莫他特能降低糖尿病性肾炎或肾炎综合征病人的尿蛋白。
4)炎性肠道疾病 溃疡性结肠炎和Crohn病是炎性肠道疾病的典型病例,也是一种自身免疫性疾病,主要发生在年轻的成年病人的肠道中。甲磺酸卡莫他特对右旋糖酐硫酸酯诱导的大鼠溃疡性结肠炎模型试验有效,临床上对溃疡性结肠炎有治疗作用。
药代动力学 
本品口服吸收迅速,给药40min后,其活性代谢物4- (4-胍基苯甲酰氧基)苯乙酸即达到血药浓度的峰值(84ng/ml)。血中半衰期为73min,给药后5~6h 内从尿中的排泄量为20%,尿中大部他的代谢物为4- 胍基苯甲酸,其少量为4-苯乙酰。

原产地英文商品名:
FOIPAN(フオイパン) 
原产地英文药品名:
CAMOSTAT MESILATE
原产地英文化合物名称:
 N,N-Dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate 
monomethanesulfonate
中文参考商品译名:
FOIPAN(フオイパン) 
中文参考药品译名:
 甲磺酸卡莫司他
生产厂家中文参考译名:
日本小野药品株式会社
生产厂家英文名:
ONO PHARMACEUTICAL CO., LTD. 

 

 

 

 

 

 

 

 

 

 

外文说明

(免责声明:本说明书仅供参考,不作为治疗的依据,不可取代任何医生、药剂师等专业性的指导。本站不提供治疗建议,药物是否适合您,请专业医生(或药剂师)决定。)

Description

This medicine is a proteolytic enzyme inhibitor that inhibits digestive enzymes in pancreatic fluid (e.g., trypsin) and suppresses abnormal increases of the enzyme activity, leading to ameliorating inflammatory symptoms and pain associated with pancreatitis.

This medicine also ameliorates symptoms by inhibiting trypsin in digestive juice flowing back to the esophagus after gastric surgery.

Presentation

100Tablets

Feature

white tablet, diameter 6.6 mm, thickness 4.1 mm

Active Ingredients

Camostat mesilate

Effect/Efficacy

It is usually used in the treatment of acute symptoms of chronic pancreatitis and postoperative reflux esophagitis.

This medicine is a proteolytic enzyme inhibitor that inhibits digestive enzymes in pancreatic fluid (e.g., trypsin) and suppresses abnormal increases of the enzyme activity, leading to ameliorating inflammatory symptoms and pain associated with pancreatitis.
This medicine also ameliorates symptoms by inhibiting trypsin in digestive juice flowing back to the esophagus after gastric surgery.


Usage/Dosage

● General dosage:
- Chronic pancreatitis:
In general, take 2 tablets (200 mg of the active ingredient) at a time, 3 times a day.
The dosage may be adjusted according to symptoms of the patient.
- Postoperative reflux esophagitis:
In general, take 1 tablet (100 mg of the active ingredient) at a time, 3 times a day after each meal.

● Strictly follow the instructions in all cases.
● If you miss a dose, take the missed dose as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. You should never take two doses at one time.
● If you accidentally take more than your prescribed dose, consult with your doctor or pharmacist.
● Do not stop taking this medicine unless your doctor instructs you to do so.

Cautions

If you have previously experienced any allergic reactions (itch, rash, etc.) to any medicines.
If you are pregnant or breastfeeding.
If you are taking any other medicinal products. (Some medicines may interact to enhance or diminish medicinal effects. Beware of over-the-counter medicines and dietary supplements as well as other prescription medicines.)

Contraindication

● The most commonly reported adverse reactions are following symptoms. If any of these symptoms occur, consult with your doctor or pharmacist.
- rash, itch, nausea, abdominal bloating and diarrhea.

● The symptoms described below are rarely seen as initial symptoms of the adverse reactions indicated in brackets. If any of these symptoms occur, stop taking this medicine and see your doctor immediately.
- breathing difficulty, cold sweat, shortness of breath [shock, anaphylactoid symptoms]
- nasal bleeding, gum bleeding, subcutaneous bleeding in limbs [thrombocytopenia]
- general malaise, loss of appetite, yellow discoloration of the skin or conjunctiva [liver dysfunction, jaundice]
- numbness of limbs or lips, muscle weakness, paralysis in the limbs [hyperkalemia]

The above symptoms do not describe all the adverse reactions to this medicine. Consult with your doctor or pharmacist if you notice any symptoms of concern other than those listed above.