Efavirenz/lamivudine/tenofovir (EFV/3TC/TDF), sold under the brand nameTelura, is a fixed dose combination medication for the treatment of HIV/AIDS.[1] It combines efavirenz, lamivudine, and tenofovir.[1] As of 2010 it is a first line option in the developing world.[1] It is taken by mouth.[1]

Side effects can include joint pain, sleepiness, headaches, depression, trouble sleeping, and itchiness.[1] Severe side effects may include depression, psychosis, or osteonecrosis.[1] In those with a history of epilepsy, it may increase the frequency of seizures.[1] Greater care should also be taken in those with kidney problems.[1] It is unclear if use during pregnancy is safe.[1][2]

It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[3] A year of medication is estimated to costs 154 USD in the developing world as of 2011.[1] The combination received tentative approval in the United States in 2014.[4] Its availability and importance is supported by Medecins Sans Frontieres.[5]